IGT was diagnosed by American Diabetes Association (ADA) guidelines 1 requiring the following two criteria: 1) Plasma glucose two hours (2hrPG) after consuming 75 g of glucose is at least 140 mg/dl but below 200 mg/dl and 2) fasting plasma glucose (FPG) level is less than 126 mg/dl. Patients enrolled were aged 18 years of age or older identified to have either 1) IGT 2) IFG or 3) metabolic syndrome. Because of the association of derangements in these metabolic abnormalities with endothelial dysfunction, brachial artery reactivity was also assessed before and after therapy. To assess the efficacy of this popular nutritional supplement, we performed a randomized controlled trial designed to investigate the effects of daily chromium picolinate supplementation for six months at two dose levels on serum measures of glucose tolerance and insulin sensitivity. 11 Indeed, one of the more common nutrition-related questions posed by patients with or at risk for diabetes to practicing endocrinologists concerns the effectiveness of chromium. 10 In 2002, estimated sales of chromium-based supplements was $85 million (USD). 9 Chromium picolinate is widely marketed to the public with diverse health claims pertaining to glucose metabolism, insulin action, muscle mass, weight control, and diabetes prevention. The micronutrient chromium (Cr) is of interest in this regard as a potential means of improving glucose tolerance 7, 8 by reducing insulin resistance. 4 Intensive diet and lifestyle change can play an important role in diabetes prevention 5 though adherence to these regimens is often difficult. While pharmacotherapy with such drugs as metformin, acarbose, orlistat, and thiazolidinediones can reduce risk of T2D, 3 their cost and potential adverse effects can be objectionable to patients who do not yet have an actual disease. 1 Endothelial dysfunction is also associated with increased risk for diabetes and is directly linked to insulin resistance 2 and hyperglycemia. Made in our clean room facility, here in the UK.Impaired Glucose Tolerance (IGT), impaired fasting glucose (IFG), and metabolic syndrome are considered precursors to type 2 diabetes (T2D) mellitus. It therefore promotes the breakdown of fat, carbohydrates and proteinsĮach capsule of Metabolics Chromium picolinate contains 200mcg elemental chromium. It is believed that when the insulin receptor is activated chromium moves into the cell, binds to a peptide enhancing the insulin receptor activityĬontributes to normal macronutrient metabolism by facilitating the action of insulin. It binds to insulin receptors on cell surfaces, activating them and stimulating glucose uptake by the cells for energy. ![]() Insulin is a hormone secreted by the pancreas when blood glucose increases after a meal. ![]() It does this by participating in glucose metabolism, enhancing the effects of insulin. Why Take Chromium Picolinate?Ĭhromium contributes to the maintenance of normal blood glucose levels. Hexavalent (Chromium 6+), a toxic form resulting from pollution. Chromium absorption is enhanced by Vitamin C and is stored in the liver. Chromium is poorly absorbed from the digestive tract, between 0.4% -2.5% of the amount consumed, the rest is excreted. Trivalent (Chromium 3+) which is biologically available in foods such as broccoli, meat, tea and grains although levels of Chromium in foods vary depending on the soil content. ![]() ![]() Metabolics uses Chromium Picolinate, which is an effective source of chromium, with superior bio availability, making it an excellent trivalent source of chromium.Ĭhromium is an important trace mineral. Chromium Picolinate Supplements In Stock - Order by 3pm for same day dispatch
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